Jason R. Abbott

Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRAS ^G12C Inhibitor

Joachim Bröker, Alex G. Waterson, Chris A. Smethurst et al. · Journal of Medicinal Chemistry · 2022 · 81 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +16

Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS

Timothy R. Hodges, Jason R. Abbott, Andrew J. Little et al. · Journal of Medicinal Chemistry · 2018 · 56 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +16

Amides as Excellent Mimics of Phosphate Linkages in RNA

Chelliah Selvam, Siji Thomas, Jason R. Abbott et al. · Angewandte Chemie International Edition · 2011 · 50 citations

Life Sciences, Chemical Biology, Molecular Biology +17

High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling

Michael C. Burns, Jennifer E. Howes, Qi Sun et al. · Analytical Biochemistry · 2018 · 48 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling

Jason R. Abbott, Timothy R. Hodges, R. Nathan Daniels et al. · Journal of Medicinal Chemistry · 2018 · 42 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +17