Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data

Joshua C. Denny, Lisa Bastarache, Marylyn D. Ritchie, +33

Nature Biotechnology

Genome-wide Association StudyHealth InformaticsGenotype-phenotype AssociationClinical DatabaseGenetic Epidemiology +10

Tyr-95 and Ile-172 in Transmembrane Segments 1 and 3 of Human Serotonin Transporters Interact to Establish High Affinity Recognition of Antidepressants

L. Keith Henry, Julie R. Field, Erika M. Adkins, +5

Journal of Biological Chemistry

Drug TargetNeurotransmitterMolecular BiologyNormal Serotonin RecognitionHigh Affinity Recognition +16

Biobanks and Electronic Medical Records: Enabling Cost-Effective Research

Erica Bowton, Julie R. Field, Sunny Wang, +13

Science Translational Medicine

Electronic health record design and implementation for pharmacogenomics: a local perspective

Josh F. Peterson, Erica Bowton, Julie R. Field, +9

Genetics in Medicine

Medical RecordsClinical DatabaseDigital HealthLocal PerspectiveOmics +8

Clinician Perspectives on Using Pharmacogenomics in Clinical Practice

Kim M. Unertl, Habiba Jaffa, Julie R. Field, +2

Personalized Medicine

Attitudes of clinicians following large-scale pharmacogenomics implementation

Josh F. Peterson, Julie R. Field, Yaping Shi, +9

The Pharmacogenomics Journal

Personalized TreatmentPharmacogenomicsPharmacogeneticsPublic HealthMedicine +2

Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index

Robert M. Cronin, Julie R. Field, Yuki Bradford, +32

Frontiers in Genetics

Identification of Positive Allosteric Modulators VU0155094 (ML397) and VU0422288 (ML396) Reveals New Insights into the Biology of Metabotropic Glutamate Receptor 7

Nidhi Jalan‐Sakrikar, Julie R. Field, Rebecca Klar, +20

ACS Chemical Neuroscience

Molecular BiologyNew InsightsMglu7 ActivitySocial SciencesDifferential Activity +15

Discovery, Synthesis, and Structure–Activity Relationship Development of a Series of <i>N</i>-4-(2,5-Dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): Characterization of a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu₄) with Oral Efficacy in an Antiparkinsonian Animal Model

Carrie K. Jones, Darren W. Engers, Analisa D. Thompson, +15

Journal of Medicinal Chemistry

Antiparkinsonian Animal ModelBrain ExposureWell-established Antiparkinsonian ModelPeptide SciencePharmacotherapy +18

Structural determinants of species‐selective substrate recognition in human and <i>Drosophila</i> serotonin transporters revealed through computational docking studies

Kristian Kaufmann, Eric S. Dawson, L. Keith Henry, +3

Proteins Structure Function and Bioinformatics

Substrate SelectivityDrug TargetNeurotransmitterMolecular BiologyChemical Biology +16