Antipsychotic Drug-Like Effects of the Selective M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100

Nellie Byun, Michael Grannan, Michael Bubser, +18

Neuropsychopharmacology

PsychiatryFunctional SelectivityMedicinePsychopharmacologySchizophrenia +7

The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson’s Disease

Zixiu Xiang, Analisa D. Thompson, John T. Brogan, +22

ACS Chemical Neuroscience

Chemical Modulation of Mutant mGlu₁ Receptors Derived from Deleterious <i>GRM1</i> Mutations Found in Schizophrenics

Hyekyung P. Cho, Pedro M. García-Barrantes, John T. Brogan, +10

ACS Chemical Biology

Deleterious NssnpsSynaptic SignalingSocial SciencesMolecular PharmacologyPsychiatric Genetics +15

Total Synthesis and Biological Evaluation of Phidianidines A and B Uncovers Unique Pharmacological Profiles at CNS Targets

John T. Brogan, Sydney L. Stoops, Craig W. Lindsley

ACS Chemical Neuroscience

Bioorganic ChemistryIndole Acetic AcidsPharmacotherapyPharmaceutical ChemistryMolecular Pharmacology +19

Synthesis and Structure–Activity Relationships of Allosteric Potentiators of the M₄ Muscarinic Acetylcholine Receptor

J. Phillip Kennedy, Thomas M. Bridges, Patrick R. Gentry, +7

ChemMedChem

Combinatorial ChemistryEc50 ValuesChemical BiologyStructure–activity RelationshipsPharmaceutical Chemistry +16

Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties

Thomas M. Bridges, Ashley E. Brady, J. Phillip Kennedy, +9

Bioorganic & Medicinal Chemistry Letters

MedicineDrug DiscoveryDiversity-oriented SynthesisRational Drug DesignPrivileged Structure Moieties +5

Total Synthesis and Biological Evaluation of the Marine Bromopyrrole Alkaloid Dispyrin: Elucidation of Discrete Molecular Targets with Therapeutic Potential

J. Phillip Kennedy, John T. Brogan, Craig W. Lindsley

Journal of Natural Products

Therapeutic PotentialPharmaceutical ScienceBioorganic ChemistryGram ScaleSynthetic Dispyrin +16

Total Synthesis of (+)-7-Bromotrypargine and Unnatural Analogues: Biological Evaluation Uncovers Activity at CNS Targets of Therapeutic Relevance

John T. Brogan, Sydney L. Stoops, Brenda C. Crews, +2

ACS Chemical Neuroscience

Bioorganic ChemistryEngineeringTherapeutic RelevancePharmaceutical ChemistryUnnatural Analogues +14

Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonists

L. Michelle Lewis, Douglas J. Sheffler, Richard D. Williams, +9

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyFunctional SelectivityMedicineMechanism Of ActionReceptor (Biochemistry) +3

Progress toward the synthesis of piperazimycin A: exploration of the synthesis of γ-hydroxy and γ-chloropiperazic acids

J. Phillip Kennedy, John T. Brogan, Craig W. Lindsley

Tetrahedron Letters

Medicinal ChemistryBiosynthesisBioorganic ChemistryEngineeringBiochemistry +7