Rebecca L. Weiner

Discovery of VU0467485/AZ13713945: An M₄ PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia

Michael R. Wood, Meredith J. Noetzel, Bruce J. Melancon et al. · ACS Medicinal Chemistry Letters · 2016 · 54 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Design and Synthesis of <i>N</i>-Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu₃ NAMs

Julie L. Engers, Katrina A. Bollinger, Rebecca L. Weiner et al. · ACS Medicinal Chemistry Letters · 2017 · 44 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs

Michael R. Wood, Meredith J. Noetzel, Michael S. Poslusney et al. · Bioorganic & Medicinal Chemistry Letters · 2016 · 42 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +9

Design and Synthesis of mGlu₂NAMs with Improved Potency and CNS Penetration Based on a Truncated Picolinamide Core

Katrina A. Bollinger, Andrew S. Felts, Christopher J. Brassard et al. · ACS Medicinal Chemistry Letters · 2017 · 38 citations · Full text

Pharmacy, Neuroscience, Pharmacology +12

Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides

James C. Tarr, Michael R. Wood, Meredith J. Noetzel et al. · Bioorganic & Medicinal Chemistry Letters · 2017 · 27 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +7