Alison R. Gregro

Structure-Based Design of Potent and Selective Cell-Permeable Inhibitors of Human β-Secretase (BACE-1)

Shawn J. Stachel, Craig A. Coburn, Thomas G. Steele et al. · Journal of Medicinal Chemistry · 2004 · 277 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind β-secretase in a N-terminal 10s-loop down conformation

Shaun R. Stauffer, Matthew G. Stanton, Alison R. Gregro et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 62 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +10

Discovery of Isonicotinamide Derived β-Secretase Inhibitors:  In Vivo Reduction of β-Amyloid

Matthew G. Stanton, Shaun R. Stauffer, Alison R. Gregro et al. · Journal of Medicinal Chemistry · 2007 · 61 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core

Michael R. Wood, Meredith J. Noetzel, Julie L. Engers et al. · Bioorganic & Medicinal Chemistry Letters · 2016 · 23 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Evaluating scoring functions for docking and designing β-secretase inhibitors

M. Katharine Holloway, Georgia B. McGaughey, Craig A. Coburn et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 21 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12