Thomas G. Steele

Structure-Based Design of Potent and Selective Cell-Permeable Inhibitors of Human β-Secretase (BACE-1)

Shawn J. Stachel, Craig A. Coburn, Thomas G. Steele et al. · Journal of Medicinal Chemistry · 2004 · 277 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

In Vitro and in Vivo Evaluation of Dihydropyrimidinone C-5 Amides as Potent and Selective α_1A Receptor Antagonists for the Treatment of Benign Prostatic Hyperplasia

James C. Barrow, Philippe G. Nantermet, Harold G. Selnick et al. · Journal of Medicinal Chemistry · 2000 · 223 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Identification of a Small Molecule Nonpeptide Active Site β-Secretase Inhibitor That Displays a Nontraditional Binding Mode for Aspartyl Proteases

Craig A. Coburn, Shawn J. Stachel, Yue‐Ming Li et al. · Journal of Medicinal Chemistry · 2004 · 117 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +17

In Vivo β-Secretase 1 Inhibition Leads to Brain Aβ Lowering and Increased α-Secretase Processing of Amyloid Precursor Protein without Effect on Neuregulin-1

Sethu Sankaranarayanan, Eric A. Price, Guoxin Wu et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 100 citations

Life Sciences, Neurobiology, Neuroscience +16

Conformationally biased P3 amide replacements of β-secretase inhibitors

Shawn J. Stachel, Craig A. Coburn, Thomas G. Steele et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 66 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +14