Concepedia

In Vivo β-Secretase 1 Inhibition Leads to Brain Aβ Lowering and Increased α-Secretase Processing of Amyloid Precursor Protein without Effect on Neuregulin-1

Sethu Sankaranarayanan, Eric A. Price, Guoxin Wu, Ming‐Chih Crouthamel, Xiao‐Ping Shi, Katherine Tugusheva, Keala X. Tyler, Jason A. Kahana, Joan D. Ellis, Lixia Jin,

Journal of Pharmacology and Experimental Therapeutics · 2007 · 100 citations · 67 references

DOI

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References

67

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

Robert D. Terry, Eliezer Masliah, David P. Salmon et al. · Annals of Neurology · 1991 · 4.4K citations

, , +17

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Robert Vassar, Brian D. Bennett, Safura Babu‐Khan et al. · Science · 1999 · 3.8K citations · Full text

, , +17

Purification and cloning of amyloid precursor protein β-secretase from human brain

Sukanto Sinha, John P. Anderson, Robin Barbour et al. · Nature · 1999 · 1.6K citations

, , +14

Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity

Riqiang Yan, Michael J. Bienkowski, Mary E. Shuck et al. · Nature · 1999 · 1.4K citations

, , +14

Correlation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline

Jan Näslund · JAMA · 2000 · 1.3K citations

, , +12