Ming‐Chih Crouthamel

Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity

Rakesh Kumar, Victoria B. Knick, Sharon K. Rudolph et al. · Molecular Cancer Therapeutics · 2007 · 517 citations

Medicine, Pharmacokinetics, Pharmacology +17

Structure-Based Design of Potent and Selective Cell-Permeable Inhibitors of Human β-Secretase (BACE-1)

Shawn J. Stachel, Craig A. Coburn, Thomas G. Steele et al. · Journal of Medicinal Chemistry · 2004 · 277 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer

Anastasia Wyce, Yan Degenhardt, Yuchen Bai et al. · Oncotarget · 2013 · 177 citations · Full text

Medicine, Molecular Biology, Oncology +17

Presenilin-1 and Presenilin-2 Exhibit Distinct yet Overlapping γ-Secretase Activities

Ming‐Tain Lai, Elizabeth Chen, Ming‐Chih Crouthamel et al. · Journal of Biological Chemistry · 2003 · 169 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +10

Discovery of Novel AKT Inhibitors with Enhanced Anti-Tumor Effects in Combination with the MEK Inhibitor

Melissa Dumble, Ming‐Chih Crouthamel, Shuyun Zhang et al. · PLoS ONE · 2014 · 144 citations · Full text

Medicine, Oncology, Pharmacology +14