Combined BRAF and MEK Inhibition With Dabrafenib and Trametinib in <i>BRAF</i> V600–Mutant Colorectal Cancer

Ryan B. Corcoran, Chloé E. Atreya, Gerald S. Falchook, +17

Journal of Clinical Oncology

A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC

Helai P. Mohammad, Kimberly N. Smitheman, Chandrashekhar D. Kamat, +30

Cancer Cell

Oncogenic AgentMedicineEpigenetic ChangePharmacologyLsd1 Inhibitors +7

BET Inhibition Silences Expression of MYCN and BCL2 and Induces Cytotoxicity in Neuroblastoma Tumor Models

Anastasia Wyce, Gopinath Ganji, Kimberly N. Smitheman, +16

PLoS ONE

Mycn Copy NumberBet Family ProteinsCell RegulationOncogenic AgentMedicine +12

Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer

Anastasia Wyce, Yan Degenhardt, Yuchen Bai, +8

Oncotarget

Over-express MycBet Bromodomain ProteinsUrologyOncogenic AgentMedicine +12

The prognostic significance of Cdc6 and Cdt1 in breast cancer

Ravikiran Mahadevappa, Henrique Neves, Shun Ming Yuen, +6

Scientific Reports

A novel cuproptosis-related lncRNA signature predicts the prognosis and immune landscape in bladder cancer

Yuchen Bai, Qi Zhang, Feng Liu, +1

Frontiers in Immunology

DNA Replication Licensing Protein MCM10 Promotes Tumor Progression and Is a Novel Prognostic Biomarker and Potential Therapeutic Target in Breast Cancer

Ravikiran Mahadevappa, Henrique Neves, Shun Ming Yuen, +7

Cancers

A687V EZH2 Is a Driver of Histone H3 Lysine 27 (H3K27) Hypertrimethylation

Heidi M. Ott, Alan P. Graves, Melissa B. Pappalardi, +16

Molecular Cancer Therapeutics

Histone ModificationsA687v Ezh2Epigenetic ChangeMolecular BiologyEzh2 Activity +19

Genetic and Functional Analysis of Human P2X5 Reveals a Distinct Pattern of Exon 10 Polymorphism with Predominant Expression of the Nonfunctional Receptor Isoform

Smita Kotnis, Brendan Bingham, D. Vasilyev, +8

Molecular Pharmacology

YBX1 integration of oncogenic PI3K/mTOR signalling regulates the fitness of malignant epithelial cells

Yuchen Bai, Carolin Götz, Ginevra Chincarini, +10

Nature Communications

Cancer BiologyTumor BiologyYbx1 IntegrationSignaling PathwayPi3k/mtor Pathway +18