Xiao‐Ping Shi

Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1

Yue‐Ming Li, Min Xu, Ming‐Tain Lai et al. · Nature · 2000 · 864 citations

Molecular Pharmacology, Medicinal Chemistry, Protein Secretion +12

Presenilin 1 is linked with γ-secretase activity in the detergent solubilized state

Yue‐Ming Li, Ming‐Tain Lai, Min Xu et al. · Proceedings of the National Academy of Sciences · 2000 · 534 citations · Full text

Protein Secretion, Molecular Biology, Amyloid Precursor Protein +17

Structure-Based Design of Potent and Selective Cell-Permeable Inhibitors of Human β-Secretase (BACE-1)

Shawn J. Stachel, Craig A. Coburn, Thomas G. Steele et al. · Journal of Medicinal Chemistry · 2004 · 273 citations · Full text

Protein Secretion, Drug Target, Cell Culture +16

Presenilin-1 and Presenilin-2 Exhibit Distinct yet Overlapping γ-Secretase Activities

Ming‐Tain Lai, Elizabeth Chen, Ming‐Chih Crouthamel et al. · Journal of Biological Chemistry · 2003 · 168 citations · Full text

The Pro Domain of β-Secretase Does Not Confer Strict Zymogen-like Properties but Does Assist Proper Folding of the Protease Domain

Xiao‐Ping Shi, Elizabeth Chen, Kuo‐Chang Yin et al. · Journal of Biological Chemistry · 2001 · 123 citations · Full text