Katherine Tugusheva

Structure-Based Design of Potent and Selective Cell-Permeable Inhibitors of Human β-Secretase (BACE-1)

Shawn J. Stachel, Craig A. Coburn, Thomas G. Steele et al. · Journal of Medicinal Chemistry · 2004 · 277 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

A Sensitive Aβ Oligomer Assay Discriminates Alzheimer's and Aged Control Cerebrospinal Fluid

Mary J. Savage, Juliya Kalinina, Abigail Wolfe et al. · Journal of Neuroscience · 2014 · 189 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +17

First Demonstration of Cerebrospinal Fluid and Plasma Aβ Lowering with Oral Administration of a β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates

Sethu Sankaranarayanan, Marie A. Holahan, Dennis Colussi et al. · Journal of Pharmacology and Experimental Therapeutics · 2008 · 106 citations

Medicine, Pharmacokinetics, Pharmacology +17

In Vivo β-Secretase 1 Inhibition Leads to Brain Aβ Lowering and Increased α-Secretase Processing of Amyloid Precursor Protein without Effect on Neuregulin-1

Sethu Sankaranarayanan, Eric A. Price, Guoxin Wu et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 100 citations

Life Sciences, Neurobiology, Neuroscience +16

Intracellular Clusterin Interacts with Brain Isoforms of the Bridging Integrator 1 and with the Microtubule-Associated Protein Tau in Alzheimer's Disease

Yuan Zhou, Ikuo Hayashi, Jacky Wong et al. · PLoS ONE · 2014 · 92 citations · Full text

Life Sciences, Genetics, Neuroscience +17