Katherine Tugusheva - Concepedia

Concepedia

Author

Katherine Tugusheva

United States Military Academy

Also Known As

Katherine Tugusheva, Katherine Tugusheva (602368)

23

Publications

1.2K

Citations

17

H-Index

39

Concepts

All Affiliations

United States Military Academy Merck & Co., Inc., Rahway, NJ, USA (United States)

KT

About

Katherine Tugusheva is an author at United States Military Academy specializing in medicine, drug discovery, and natural sciences.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	10	10	618
2	Natural Sciences	7	7	495
3	Biochemistry	7	7	482
4	Cell Biology	2	2	117
5	Health Sciences	1	1	81

Katherine Tugusheva

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17

Publications

1.2K

Citations

17

H-Index

	Year	Citations
Structure-Based Design of Potent and Selective Cell-Permeable Inhibitors of Human β-Secretase (BACE-1) Shawn J. Stachel, Craig A. Coburn, Thomas G. Steele, Journal of Medicinal Chemistry Protein SecretionDrug TargetCell CultureProtein PurificationHuman β-Secretase	2004	273
A Sensitive Aβ Oligomer Assay Discriminates Alzheimer's and Aged Control Cerebrospinal Fluid Mary J. Savage, Juliya Kalinina, Abigail Wolfe, Journal of Neuroscience	2014	169
First Demonstration of Cerebrospinal Fluid and Plasma Aβ Lowering with Oral Administration of a β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates Sethu Sankaranarayanan, Marie A. Holahan, Dennis Colussi, Journal of Pharmacology and Experimental Therapeutics	2008	105
In Vivo β-Secretase 1 Inhibition Leads to Brain Aβ Lowering and Increased α-Secretase Processing of Amyloid Precursor Protein without Effect on Neuregulin-1 Sethu Sankaranarayanan, Eric A. Price, Guoxin Wu, Journal of Pharmacology and Experimental Therapeutics	2007	100
Discovery of Oxadiazoyl Tertiary Carbinamine Inhibitors of β-Secretase (BACE-1) Hemaka A. Rajapakse, Philippe G. Nantermet, Harold G. Selnick, Journal of Medicinal Chemistry	2006	82
Intracellular Clusterin Interacts with Brain Isoforms of the Bridging Integrator 1 and with the Microtubule-Associated Protein Tau in Alzheimer's Disease Yuan Zhou, Ikuo Hayashi, Jacky Wong, PLoS ONE Genetic EpidemiologyNeurochemical BiomarkersCytoskeletonBrain IsoformsSynaptic Signaling	2014	81
β-Secretase Cleavage at Amino Acid Residue 34 in the Amyloid β Peptide Is Dependent upon γ-Secretase Activity Xiao-Ping Shi, Katherine Tugusheva, James E. Bruce, Journal of Biological Chemistry	2003	72
Characterization of plasma β‐secretase (BACE1) activity and soluble amyloid precursor proteins as potential biomarkers for Alzheimer's disease Guoxin Wu, Sethu Sankaranarayanan, Jacky Wong, Journal of Neuroscience Research	2012	65
Discovery and X-ray Crystallographic Analysis of a Spiropiperidine Iminohydantoin Inhibitor of β-Secretase James C. Barrow, Shaun R. Stauffer, Kenneth E. Rittle, Journal of Medicinal Chemistry Crystal StructureBace-1 EnzymeMolecular BiologyChemical BiologyPharmaceutical Chemistry	2008	59
Biochemical and cell-based assays for characterization of BACE-1 inhibitors Beth Pietrak, Ming‐Chih Crouthamel, Katherine Tugusheva, Analytical Biochemistry Medicinal ChemistryDrug TargetBiochemistryMedicineNatural Sciences	2005	48

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