Dennis Colussi

First Demonstration of Cerebrospinal Fluid and Plasma Aβ Lowering with Oral Administration of a β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates

Sethu Sankaranarayanan, Marie A. Holahan, Dennis Colussi et al. · Journal of Pharmacology and Experimental Therapeutics · 2008 · 106 citations

Medicine, Pharmacokinetics, Pharmacology +17

<i>LRRTM3</i> promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease

John Majercak, William J. Ray, Amy S. Espeseth et al. · Proceedings of the National Academy of Sciences · 2006 · 94 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +17

Discovery of Oxadiazoyl Tertiary Carbinamine Inhibitors of β-Secretase (BACE-1)

Hemaka A. Rajapakse, Philippe G. Nantermet, Harold G. Selnick et al. · Journal of Medicinal Chemistry · 2006 · 83 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Ribosome-Templated Azide–Alkyne Cycloadditions: Synthesis of Potent Macrolide Antibiotics by In Situ Click Chemistry

Ian Glassford, Christiana N. Teijaro, Samer S. Daher et al. · Journal of the American Chemical Society · 2016 · 66 citations

Pharmacy, Medicinal Chemistry, Molecular Biology +17

Discovery of Isonicotinamide Derived β-Secretase Inhibitors:  In Vivo Reduction of β-Amyloid

Matthew G. Stanton, Shaun R. Stauffer, Alison R. Gregro et al. · Journal of Medicinal Chemistry · 2007 · 61 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17