Dennis Colussi

First Demonstration of Cerebrospinal Fluid and Plasma Aβ Lowering with Oral Administration of a β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates

Sethu Sankaranarayanan, Marie A. Holahan, Dennis Colussi et al. · Journal of Pharmacology and Experimental Therapeutics · 2008 · 105 citations

<i>LRRTM3</i> promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease

John Majercak, William J. Ray, Amy S. Espeseth et al. · Proceedings of the National Academy of Sciences · 2006 · 94 citations · Full text

Molecular Biology, Synaptic Signaling, Late-onset Alzheimer +21

Discovery of Oxadiazoyl Tertiary Carbinamine Inhibitors of β-Secretase (BACE-1)

Hemaka A. Rajapakse, Philippe G. Nantermet, Harold G. Selnick et al. · Journal of Medicinal Chemistry · 2006 · 82 citations · Full text

Ribosome-Templated Azide–Alkyne Cycloadditions: Synthesis of Potent Macrolide Antibiotics by In Situ Click Chemistry

Ian Glassford, Christiana N. Teijaro, Samer S. Daher et al. · Journal of the American Chemical Society · 2016 · 64 citations · Full text

Discovery of Isonicotinamide Derived β-Secretase Inhibitors:  In Vivo Reduction of β-Amyloid

Matthew G. Stanton, Shaun R. Stauffer, Alison R. Gregro et al. · Journal of Medicinal Chemistry · 2007 · 59 citations · Full text

Beta-secretase Inhibition, Neurochemical Biomarkers, Beta-amyloid Lowering +16