Hemaka A. Rajapakse

Structure-Based Design of Potent and Selective Cell-Permeable Inhibitors of Human β-Secretase (BACE-1)

Shawn J. Stachel, Craig A. Coburn, Thomas G. Steele et al. · Journal of Medicinal Chemistry · 2004 · 273 citations · Full text

Protein Secretion, Drug Target, Cell Culture +16

Enantioselective total synthesis of altohyrtin C (spongistatin 2)

David A. Evans, B. Wesley Trotter, Paul J. Coleman et al. · Tetrahedron · 1999 · 155 citations

Natural Product Synthesis, Spongistatin 2, Enantioselective Synthesis +1

First Demonstration of Cerebrospinal Fluid and Plasma Aβ Lowering with Oral Administration of a β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates

Sethu Sankaranarayanan, Marie A. Holahan, Dennis Colussi et al. · Journal of Pharmacology and Experimental Therapeutics · 2008 · 105 citations

Enantioselective Oxidation of Secondary Alcohols Using a Chiral Nitroxyl (<i>N</i>-Oxoammonium salt) Catalyst

Scott D. Rychnovsky, Terri L. McLernon, Hemaka A. Rajapakse · The Journal of Organic Chemistry · 1996 · 94 citations

Chemical Engineering, Engineering, Donut Icon +11

Discovery of Oxadiazoyl Tertiary Carbinamine Inhibitors of β-Secretase (BACE-1)

Hemaka A. Rajapakse, Philippe G. Nantermet, Harold G. Selnick et al. · Journal of Medicinal Chemistry · 2006 · 82 citations · Full text