Marie A. Holahan

Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy

Robert W. Myers, Hong-Ping Guan, Juliann Ehrhart et al. · Science · 2017 · 344 citations

Life Sciences, Biochemistry, Pharmacology +17

Preclinical Characterization of¹⁸F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles

Eric D. Hostetler, Abbas Walji, Zhizhen Zeng et al. · Journal of Nuclear Medicine · 2016 · 284 citations · Full text

Life Sciences, Neurology, Neuroscience +17

Discovery of 6-(Fluoro-¹⁸<i>F</i>)-3-(1<i>H</i>-pyrrolo[2,3-<i>c</i>]pyridin-1-yl)isoquinolin-5-amine ([¹⁸F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs)

Abbas Walji, Eric D. Hostetler, Harold G. Selnick et al. · Journal of Medicinal Chemistry · 2016 · 180 citations

Life Sciences, Neurobiology, Neuroscience +17

Metabolism-Directed Optimization of 3-Aminopyrazinone Acetamide Thrombin Inhibitors. Development of an Orally Bioavailable Series Containing P1 and P3 Pyridines

Christopher S. Burgey, Kyle A. Robinson, Terry A. Lyle et al. · Journal of Medicinal Chemistry · 2003 · 121 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17

First Demonstration of Cerebrospinal Fluid and Plasma Aβ Lowering with Oral Administration of a β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates

Sethu Sankaranarayanan, Marie A. Holahan, Dennis Colussi et al. · Journal of Pharmacology and Experimental Therapeutics · 2008 · 106 citations

Medicine, Pharmacokinetics, Pharmacology +17