A futile metabolic cycle activated in adipocytes by antidiabetic agents

Hong-Ping Guan, Yong Li, Mette V. Jensen, +3

Nature Medicine

Metabolic SyndromeBiochemistryMedicineFutile Metabolic CycleDiabetes +9

Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy

Robert W. Myers, Hong-Ping Guan, Juliann Ehrhart, +46

Science

Cardiac MuscleCardiovascular PharmacologyGlucose HomeostasisMetabolic RemodelingCardiovascular Function +21

Corepressors selectively control the transcriptional activity of PPARγ in adipocytes

Hong-Ping Guan, Takahiro Ishizuka, Patricia C. Chui, +2

Genes & Development

PPARγ regulates adipose triglyceride lipase in adipocytes in vitro and in vivo

Erin E. Kershaw, Michael Schupp, Hong-Ping Guan, +3

American Journal of Physiology-Endocrinology and Metabolism

Metabolic SyndromeAtgl MrnaBiochemistryAtgl ExpressionMedicine +13

PPARγ regulates adipocyte cholesterol metabolism via oxidized LDL receptor 1

Patricia C. Chui, Hong-Ping Guan, Michael Lehrke, +1

Journal of Clinical Investigation

Insulin SignalingOxidative StressMetabolic SyndromeMetabolic SignalingDyslipidemia +16

Glucagon receptor antagonism induces increased cholesterol absorption

Hong-Ping Guan, Xiaodong Yang, Ku Lu, +20

Journal of Lipid Research

Accelerated Fatty Acid Oxidation in Muscle Averts Fasting-induced Hepatic Steatosis in SJL/J Mice

Hong-Ping Guan, Joseph L. Goldstein, Michael S. Brown, +1

Journal of Biological Chemistry

Diet-dependent cardiovascular lipid metabolism controlled by hepatic LXRα

Michael Lehrke, Corinna Lebherz, Segan C. Millington, +5

Cell Metabolism

Lipid NutritionLiver PhysiologyPhysiologyMetabolismHepatic Lxrα +2

Discovery of MK-8722: A Systemic, Direct Pan-Activator of AMP-Activated Protein Kinase

Danqing Feng, Tesfaye Biftu, F. Anthony Romero, +17

ACS Medicinal Chemistry Letters

Early Generation CompoundsMetabolic RemodelingInsulin SignalingMetabolic SyndromeMolecular Pharmacology +25

Pharmacological AMPK activation induces transcriptional responses congruent to exercise in skeletal and cardiac muscle, adipose tissues and liver

Eric S. Muise, Hong-Ping Guan, Jinqi Liu, +28

PLoS ONE

Cardiac MusclePhysical ActivityMuscle FunctionMetabolic RemodelingMetabolic Syndrome +16