A futile metabolic cycle activated in adipocytes by antidiabetic agents

The hormone resistin links obesity to diabetes

Claire M. Steppan, Shannon T. Bailey, Savitha Bhat et al. · Nature · 2001 · 4.8K citations

Life Sciences, Biochemistry, Endocrinology +12

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

Jürgen M. Lehmann, Linda B. Moore, Tracey Smith-Oliver et al. · Journal of Biological Chemistry · 1995 · 3.6K citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.

Peter Tontonoz, E Hu, Reed A. Graves et al. · Genes & Development · 1994 · 2.2K citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +17

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

Steven A. Kliewer, Scott S. Sundseth, Stacey A. Jones et al. · Proceedings of the National Academy of Sciences · 1997 · 2.2K citations · Full text

Life Sciences, Molecular Biology, Pharmacology +16

PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro

Evan D. Rosen, Pasha Sarraf, Amy E. Troy et al. · Molecular Cell · 1999 · 2.1K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +12