Abigail Wolfe

Inhibitors of Strand Transfer That Prevent Integration and Inhibit HIV-1 Replication in Cells

Daria J. Hazuda, Peter J. Felock, Marc Witmer et al. · Science · 2000 · 1.1K citations

Life Sciences, Medicinal Chemistry, Molecular Biology +16

Tumors secreting human TNF/cachectin induce cachexia in mice

Allen Oliff, Deborah Defeo-Jones, MARK E. BOYER et al. · Cell · 1987 · 640 citations

Medicine, Immunology, Oncology +12

Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes

Jay A. Grobler, Kara A. Stillmock, Binghua Hu et al. · Proceedings of the National Academy of Sciences · 2002 · 396 citations

Life Sciences, Biology, Molecular Biology +17

HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase

Amy S. Espeseth, Peter J. Felock, Abigail Wolfe et al. · Proceedings of the National Academy of Sciences · 2000 · 318 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +17

Design and Synthesis of 8-Hydroxy-[1,6]Naphthyridines as Novel Inhibitors of HIV-1 Integrase in Vitro and in Infected Cells

Linghang Zhuang, John Wai, Mark W. Embrey et al. · Journal of Medicinal Chemistry · 2003 · 270 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17