Marc Witmer

Inhibitors of Strand Transfer That Prevent Integration and Inhibit HIV-1 Replication in Cells

Daria J. Hazuda, Peter J. Felock, Marc Witmer et al. · Science · 2000 · 1.1K citations

Hiv-1 Integrase, Viral Replication, Immunology +19

Discovery of Raltegravir, a Potent, Selective Orally Bioavailable HIV-Integrase Inhibitor for the Treatment of HIV-AIDS Infection

Vincenzo Summa, Alessia Petrocchi, Fabio Bonelli et al. · Journal of Medicinal Chemistry · 2008 · 624 citations · Full text

Antiviral Drug, Medicinal Chemistry, Antiviral Drug Development +16

Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes

Jay A. Grobler, Kara A. Stillmock, Binghua Hu et al. · Proceedings of the National Academy of Sciences · 2002 · 395 citations · Full text

Hiv-1 Integrase, Active Site Mutants, Molecular Biology +19

A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase

Daria J. Hazuda, Neville J. Anthony, Robert Gomez et al. · Proceedings of the National Academy of Sciences · 2004 · 332 citations · Full text

Hiv-1 Integrase, Immunology, Cell Culture +17

HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase

Amy S. Espeseth, Peter J. Felock, Abigail Wolfe et al. · Proceedings of the National Academy of Sciences · 2000 · 317 citations · Full text