Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients

Angélica Jayk Bernal, Monica Maria Gomes da Silva, Dany Badibanga Musungaie, +18

New England Journal of Medicine

Inhibitors of Strand Transfer That Prevent Integration and Inhibit HIV-1 Replication in Cells

Daria J. Hazuda, Peter J. Felock, Marc Witmer, +8

Science

Hiv-1 IntegraseViral ReplicationImmunologyMolecular BiologyStrand Transfer +17

Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes

Jay A. Grobler, Kara A. Stillmock, Binghua Hu, +11

Proceedings of the National Academy of Sciences

Hiv-1 IntegraseActive Site MutantsMolecular BiologyChemical BiologyIn Active Site +17

A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase

Daria J. Hazuda, Neville J. Anthony, Robert Gomez, +30

Proceedings of the National Academy of Sciences

Hiv-1 IntegraseImmunologyCell CulturePharmacotherapyAntiviral Drug +15

HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase

Amy S. Espeseth, Peter J. Felock, Abigail Wolfe, +9

Proceedings of the National Academy of Sciences

A 7-Deaza-Adenosine Analog Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication with Excellent Pharmacokinetic Properties

David B. Olsen, Anne B. Eldrup, Linda Bartholomew, +17

Antimicrobial Agents and Chemotherapy

Viral RnaBiochemistryViral HepatitisDrug DiscoveryMedicine +13

<i>In Vitro</i>Characterization of MK-1439, a Novel HIV-1 Nonnucleoside Reverse Transcriptase Inhibitor

Ming‐Tain Lai, Meizhen Feng, Jean‐Pierre Falgueyret, +16

Antimicrobial Agents and Chemotherapy

Extended-Duration MK-8591-Eluting Implant as a Candidate for HIV Treatment and Prevention

Stephanie E. Barrett, Ryan S. Teller, Seth Forster, +15

Antimicrobial Agents and Chemotherapy

Randomized Trial of Molnupiravir or Placebo in Patients Hospitalized with Covid-19

José Ramón Arribas, Sanjay Bhagani, Suzana M. Lobo, +16

NEJM Evidence

Adverse EventsClinical Infectious DiseaseCovid-19 PandemicOral ProdrugClinical Trials +12

Replication Fitness and NS5B Drug Sensitivity of Diverse Hepatitis C Virus Isolates Characterized by Using a Transient Replication Assay

Steven W. Ludmerer, Donald J. Graham, Evelyn Boots, +8

Antimicrobial Agents and Chemotherapy

Viral ReplicationTransient Replication AssayImmunologyMolecular BiologyAntiviral Drug +15