Mark W. Embrey

A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase

Daria J. Hazuda, Neville J. Anthony, Robert Gomez et al. · Proceedings of the National Academy of Sciences · 2004 · 332 citations · Full text

Hiv-1 Integrase, Immunology, Cell Culture +17

Design and Synthesis of 8-Hydroxy-[1,6]Naphthyridines as Novel Inhibitors of HIV-1 Integrase in Vitro and in Infected Cells

Linghang Zhuang, John Wai, Mark W. Embrey et al. · Journal of Medicinal Chemistry · 2003 · 266 citations · Full text

Hiv-1 Integrase, Biochemistry, Medicine +14

4-Aryl-2,4-dioxobutanoic Acid Inhibitors of HIV-1 Integrase and Viral Replication in Cells

John Wai, Melissa S. Egbertson, Linda S. Payne et al. · Journal of Medicinal Chemistry · 2000 · 187 citations · Full text

Hiv-1 Integrase, Viral Replication, Immunology +17

Inhibition of HIV-1 Ribonuclease H by a Novel Diketo Acid, 4-[5-(Benzoylamino)thien-2-yl]-2,4-dioxobutanoic Acid

Cathryn A. Shaw-Reid, Vandna Munshi, Pia Graham et al. · Journal of Biological Chemistry · 2003 · 155 citations · Full text

Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity

Jack D. Scott, Duane E. DeMong, Thomas J. Greshock et al. · Journal of Medicinal Chemistry · 2017 · 140 citations · Full text

Drug Target, Pharmacotherapy, Medicinal Chemistry +16