Melissa S. Egbertson

Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes

Jay A. Grobler, Kara A. Stillmock, Binghua Hu et al. · Proceedings of the National Academy of Sciences · 2002 · 395 citations · Full text

Hiv-1 Integrase, Active Site Mutants, Molecular Biology +19

A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase

Daria J. Hazuda, Neville J. Anthony, Robert Gomez et al. · Proceedings of the National Academy of Sciences · 2004 · 332 citations · Full text

Hiv-1 Integrase, Immunology, Cell Culture +17

HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase

Amy S. Espeseth, Peter J. Felock, Abigail Wolfe et al. · Proceedings of the National Academy of Sciences · 2000 · 317 citations · Full text

Non-peptide fibrinogen receptor antagonists. 1. Discovery and design of exosite inhibitors

George D. Hartman, Melissa S. Egbertson, Wasyl Halczenko et al. · Journal of Medicinal Chemistry · 1992 · 294 citations · Full text

Molecular Pharmacology, Biochemistry, Donut Icon +12

Design and Synthesis of 8-Hydroxy-[1,6]Naphthyridines as Novel Inhibitors of HIV-1 Integrase in Vitro and in Infected Cells

Linghang Zhuang, John Wai, Mark W. Embrey et al. · Journal of Medicinal Chemistry · 2003 · 266 citations · Full text

Hiv-1 Integrase, Biochemistry, Medicine +14