John Wai

Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes

Jay A. Grobler, Kara A. Stillmock, Binghua Hu et al. · Proceedings of the National Academy of Sciences · 2002 · 396 citations

Life Sciences, Biology, Molecular Biology +17

Optimized arylomycins are a new class of Gram-negative antibiotics

Peter A. Smith, Michael F. T. Koehler, Hany S. Girgis et al. · Nature · 2018 · 357 citations

Life Sciences, Medicinal Chemistry, Microbiology +8

A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase

Daria J. Hazuda, Neville J. Anthony, Robert Gomez et al. · Proceedings of the National Academy of Sciences · 2004 · 333 citations · Full text

Life Sciences, Pharmacokinetics, Pharmacology +17

Integrase Inhibitors and Cellular Immunity Suppress Retroviral Replication in Rhesus Macaques

Daria J. Hazuda, Steven D. Young, James P. Guare et al. · Science · 2004 · 284 citations · Full text

Life Sciences, Immunology, Pharmacology +17

Pyridinone derivatives: specific human immunodeficiency virus type 1 reverse transcriptase inhibitors with antiviral activity.

Mark E. Goldman, Jack H. Nunberg, J A O'Brien et al. · Proceedings of the National Academy of Sciences · 1991 · 279 citations

Medicine, Medicinal Chemistry, Pharmacology +14