George D. Hartman

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

Nancy E. Kohl, Charles A. Omer, Michael W. Conner et al. · Nature Medicine · 1995 · 538 citations

Farnesyltransferase Induces Regression, Tumor Biology, Chemoprevention Strategy +12

Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

Craig W. Lindsley, Zhijian Zhao, William Leister et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 497 citations · Full text

Allosteric Akt, Medicinal Chemistry, Drug Target +9

Discovery of the Dual Orexin Receptor Antagonist [(7<i>R</i>)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2<i>H</i>-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia

Christopher D. Cox, Michael J. Breslin, David B. Whitman et al. · Journal of Medicinal Chemistry · 2010 · 367 citations · Full text

Psychotropic Medication, Pharmacotherapy, Primary Insomnia +17

Non-peptide fibrinogen receptor antagonists. 1. Discovery and design of exosite inhibitors

George D. Hartman, Melissa S. Egbertson, Wasyl Halczenko et al. · Journal of Medicinal Chemistry · 1992 · 294 citations · Full text

Molecular Pharmacology, Biochemistry, Donut Icon +12

Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.

Robert B. Lobell, CharlesA. Omer, Marc Abrams et al. · PubMed · 2001 · 239 citations

Protein Transferase, H Infusion, Chemical Biology +18