Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.

Robert B. Lobell, CharlesA. Omer, Marc Abrams, +18

PubMed

Protein TransferaseH InfusionChemical BiologyTumor BiologyMolecular Pharmacology +16

Evaluation of Efficacy, Biodistribution, and Inflammation for a Potent siRNA Nanoparticle: Effect of Dexamethasone Co-treatment

Marc Abrams, Martin L. Koser, Jessica Seitzer, +11

Molecular Therapy

Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2<i>S</i>)-4-(2,5-Difluorophenyl)-<i>N</i>-[(3<i>R</i>,4<i>S</i>)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-<i>N</i>-methyl-2-phenyl-2,5-dihydro-1<i>H</i>-pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer

Christopher D. Cox, Paul J. Coleman, Michael J. Breslin, +24

Journal of Medicinal Chemistry

Hepatocyte‐Specific β‐Catenin Deletion During Severe Liver Injury Provokes Cholangiocytes to Differentiate Into Hepatocytes

Jacquelyn O. Russell, Wei‐Yu Lu, Hirohisa Okabe, +6

Hepatology

Phosphorylation of Linker Histone H1 Regulates Gene Expression In Vivo by Mimicking H1 Removal

Yali Dou, Craig A. Mizzen, Marc Abrams, +2

Molecular Cell

Expression of Asialoglycoprotein Receptor 1 in Human Hepatocellular Carcinoma

Bin Shi, Marc Abrams, Laura Sepp‐Lorenzino

Journal of Histochemistry & Cytochemistry

Asialoglycoprotein Receptor 1Human Hepatocellular CarcinomaImmunologyPathologyTumor Biology +14

Inhibition of Glucocorticoid-induced Apoptosis by Targeting the Major Splice Variants of BIM mRNA with Small Interfering RNA and Short Hairpin RNA

Marc Abrams, Noreen M. Robertson, Kyonggeun Yoon, +1

Journal of Biological Chemistry

GeneticsApoptosisRna SplicingImmunologyCell Death +16

Biodistribution of Small Interfering RNA at the Organ and Cellular Levels after Lipid Nanoparticle-mediated Delivery

Bin Shi, Ed Keough, Andrea Matter, +8

Journal of Histochemistry & Cytochemistry

NanoparticlesEngineeringLipid NanoparticlesGene DeliveryBiomedical Engineering +22

RNAi-Mediated β-Catenin Inhibition Promotes T Cell Infiltration and Antitumor Activity in Combination with Immune Checkpoint Blockade

Shanthi Ganesh, Xue Shui, Kevin P. Craig, +4

Molecular Therapy

Antitumor ActivityImmunologyImmunotherapeuticsImmune Cell TherapyImmunotherapy +16

Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl:protein transferase inhibitor.

Charles A. Omer, Zunxuan Chen, Ronald E. Diehl, +10

PubMed

Mammary CarcinomasPathologyCancer BiologyMammary Gland DevelopmentTumor Biology +17