Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration

Alexander Raven, Wei‐Yu Lu, Tak Yung Man, +11

Nature

Cholangiocytes ActOrgan DevelopmentCholangiopathiesCholangiocyte BiologyImpaired Hepatocyte Regeneration +15

Hepatic progenitor cells of biliary origin with liver repopulation capacity

Wei‐Yu Lu, Thomas G. Bird, Luke Boulter, +17

Nature Cell Biology

Liver Repopulation CapacityHepatologyBiliary TractLiver PhysiologyPathology +8

TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence

Thomas G. Bird, Miryam Müller, Luke Boulter, +31

Science Translational Medicine

Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling

Thomas G. Bird, Wei‐Yu Lu, Luke Boulter, +10

Proceedings of the National Academy of Sciences

Progenitor CellsT-regulatory CellImmunologyCell DeathStem Cell Biology +27

Paracrine cellular senescence exacerbates biliary injury and impairs regeneration

Sofía Ferreira-González, Wei‐Yu Lu, Alexander Raven, +11

Nature Communications

Mesenchymal Stem Cells and Induced Bone Marrow-Derived Macrophages Synergistically Improve Liver Fibrosis in Mice

Yusuke Watanabe, Atsunori Tsuchiya, Satoshi Seino, +11

Stem Cells Translational Medicine

Hepatocyte‐Specific β‐Catenin Deletion During Severe Liver Injury Provokes Cholangiocytes to Differentiate Into Hepatocytes

Jacquelyn O. Russell, Wei‐Yu Lu, Hirohisa Okabe, +6

Hepatology

Interleukin-13 Activates Distinct Cellular Pathways Leading to Ductular Reaction, Steatosis, and Fibrosis

Richard L. Gieseck, Thirumalai R. Ramalingam, Kevin M. Hart, +7

Immunity

Regional Differences in Human Biliary Tissues and Corresponding In Vitro–Derived Organoids

Casey A. Rimland, Samantha Grace Tilson, Carola Maria Morell, +21

Hepatology

Notch3 drives development and progression of cholangiocarcinoma

Rachel V. Guest, Luke Boulter, Benjamin J. Dwyer, +14

Proceedings of the National Academy of Sciences