Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

Jeffrey F. Ohren, Huifen Chen, A.G. Pavlovsky, +19

Nature Structural & Molecular Biology

Signal TransductionSignaling PathwayCell RegulationReceptor Tyrosine KinaseMolecular Biology +6

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

Nancy E. Kohl, Charles A. Omer, Michael W. Conner, +17

Nature Medicine

Farnesyltransferase Induces RegressionTumor BiologyChemoprevention StrategyOncogenic AgentMedicine +10

A Farnesyltransferase Inhibitor Induces Tumor Regression in Transgenic Mice Harboring Multiple Oncogenic Mutations by Mediating Alterations in Both Cell Cycle Control and Apoptosis

Rebecca E. Barrington, Mark A. Subler, Elaine Rands, +16

Molecular and Cellular Biology

Ras/myc TumorsFarnesyltransferase Inhibitor L-744,832Chemoprevention StrategySomatic VariantOncogenic Agent +12

Characterization of recombinant human farnesyl-protein transferase: Cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases

Charles A. Omer, Astrid M. Kral, Ronald E. Diehl, +4

Biochemistry

Genes for two herbicide-inducible cytochromes P-450 from Streptomyces griseolus

Charles A. Omer, Reijer Lenstra, Patricia J. Litle, +5

Journal of Bacteriology

BiosynthesisHerbicide-inducible Cytochromes P-450Cellular EnzymologyBiochemistryCytochrome P-450su2 +10

Discovery of a Novel Class of Dimeric Smac Mimetics as Potent IAP Antagonists Resulting in a Clinical Candidate for the Treatment of Cancer (AZD5582)

Edward J. Hennessy, Ammar Adam, Brian Aquila, +19

Journal of Medicinal Chemistry

Compound 14ApoptosisCell DeathPharmacotherapyTumor Biology +16

Restriction endonuclease and nucleotide sequence analyses of molecularly cloned unintegrated avian tumor virus DNA: structure of large terminal repeats in circle junctions

Richard A. Katz, Charles A. Omer, John H. Weis, +3

Journal of Virology

Viral ReplicationLarge Terminal RepeatsGeneticsMolecular BiologyPathology +15

Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl:protein transferase inhibitor.

Charles A. Omer, Zunxuan Chen, Ronald E. Diehl, +10

PubMed

Mammary CarcinomasPathologyCancer BiologyMammary Gland DevelopmentTumor Biology +17

Involvement of retrovirus reverse transcriptase-associated RNase H in the initiation of strong-stop (+) DNA synthesis and the generation of the long terminal repeat

R Resnick, Charles A. Omer, Anthony J. Faras

Journal of Virology

Viral ReplicationReverse GeneticsGeneticsViral Polymerase MechanismMolecular Biology +17

Isoprenoid diphosphate utilization by recombinant human farnesyl:protein transferase: Interactive binding between substrates and a preferred kinetic pathway

David L. Pompliano, Michael D. Schaber, Scott D. Mosser, +2

Biochemistry

Protein TransferaseMolecular BiologyAltmetric Attention ScoreInteractive BindingChemical Biology +15