Concepedia

Edward J. Hennessy

EJ

Statistics

Publications

22

Citations

1.3K

H-Index

17

Active since

1993

Affiliations

AstraZeneca (United States)(Current)

AstraZeneca (United Kingdom)

AstraZeneca (Singapore)

Massachusetts Institute of Technology

AstraZeneca (Sweden)

Edward J. Hennessy is an author at AstraZeneca (United States) specializing in medicinal chemistry, drug discovery, and pharmacy.

ORCID

Publications per year

1993–2023

22

Publications

22

Synthesis of Substituted Oxindoles from α-Chloroacetanilides via Palladium-Catalyzed C−H Functionalization

Edward J. Hennessy, Stephen L. Buchwald · Journal of the American Chemical Society · 2003 · 377 citations

, , +11

A General and Mild Copper-Catalyzed Arylation of Diethyl Malonate

Edward J. Hennessy, Stephen L. Buchwald · Organic Letters · 2002 · 186 citations

, , +16

Discovery of a Novel Class of Dimeric Smac Mimetics as Potent IAP Antagonists Resulting in a Clinical Candidate for the Treatment of Cancer (AZD5582)

Edward J. Hennessy, Ammar Adam, Brian Aquila et al. · Journal of Medicinal Chemistry · 2013 · 115 citations · Full text

, , +17

Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy

Claire Patterson, Srividya B. Balachander, Iain Grant et al. · Communications Biology · 2021 · 95 citations · Full text

, , +14

AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-xL, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia

Srividya B. Balachander, Steven W. Criscione, Kate F. Byth et al. · Clinical Cancer Research · 2020 · 69 citations

, , +13

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