Edward J. Hennessy

Synthesis of Substituted Oxindoles from α-Chloroacetanilides via Palladium-Catalyzed C−H Functionalization

Edward J. Hennessy, Stephen L. Buchwald · Journal of the American Chemical Society · 2003 · 375 citations

A General and Mild Copper-Catalyzed Arylation of Diethyl Malonate

Edward J. Hennessy, Stephen L. Buchwald · Organic Letters · 2002 · 186 citations

Chemical Engineering, Cross-coupling Reaction, Engineering +12

Discovery of a Novel Class of Dimeric Smac Mimetics as Potent IAP Antagonists Resulting in a Clinical Candidate for the Treatment of Cancer (AZD5582)

Edward J. Hennessy, Ammar Adam, Brian Aquila et al. · Journal of Medicinal Chemistry · 2013 · 112 citations · Full text

Compound 14, Apoptosis, Cell Death +18

Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy

Claire Patterson, Srividya B. Balachander, Iain Grant et al. · Communications Biology · 2021 · 89 citations · Full text

AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-xL, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia

Srividya B. Balachander, Steven W. Criscione, Kate F. Byth et al. · Clinical Cancer Research · 2020 · 64 citations