Ammar Adam

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

Adriana E. Tron, Matthew A. Belmonte, Ammar Adam et al. · Nature Communications · 2018 · 479 citations · Full text

Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer

Uddalak Bharadwaj, T. Kris Eckols, Mikhail Kolosov et al. · Oncogene · 2014 · 153 citations · Full text

Direct Stat3 Inhibitor, Medicine, Breast Cancer +8

Discovery of a Novel Class of Dimeric Smac Mimetics as Potent IAP Antagonists Resulting in a Clinical Candidate for the Treatment of Cancer (AZD5582)

Edward J. Hennessy, Ammar Adam, Brian Aquila et al. · Journal of Medicinal Chemistry · 2013 · 112 citations · Full text

Compound 14, Apoptosis, Cell Death +18

Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy

Claire Patterson, Srividya B. Balachander, Iain Grant et al. · Communications Biology · 2021 · 89 citations · Full text

The MET Inhibitor AZD6094 (Savolitinib, HMPL-504) Induces Regression in Papillary Renal Cell Carcinoma Patient–Derived Xenograft Models

Alwin G. Schuller, Evan Barry, Rhys D.O. Jones et al. · Clinical Cancer Research · 2015 · 78 citations · Full text