Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer

Uddalak Bharadwaj, T. Kris Eckols, Mikhail Kolosov, +13

Oncogene

Direct Stat3 InhibitorMedicineBreast CancerPharmacotherapyIdentified Piperlongumine +6

Cutting Edge: Clustered AU-Rich Elements Are the Target of IL-10-Mediated mRNA Destabilization in Mouse Macrophages

Raj Kishore, Julie Tebo, Mikhail Kolosov, +1

The Journal of Immunology

Immune RegulationImmunologyImmunologic MechanismInflammationIl-10-mediated Mrna Destabilization +15

Interleukin-1-mediated Stabilization of Mouse KC mRNA Depends on Sequences in both 5′- and 3′-Untranslated Regions

Julie Tebo, Shyamasree Datta, Raj Kishore, +4

Journal of Biological Chemistry

Small-molecule targeting of signal transducer and activator of transcription (STAT) 3 to treat non-small cell lung cancer

Katherine Lewis, Uddalak Bharadwaj, T. Kris Eckols, +5

Lung Cancer

Cancer ResearchSignaling PathwayMedicineSignal TransducerBronchial Neoplasm +7

Exogenous Interferon-γ Induces Endogenous Synthesis of Interferon-α and -β by Murine Macrophages for Induction of Nitric Oxide Synthase

A Q Zhou, John A. Rummage, Hong Jiang, +4

Journal of Interferon & Cytokine Research

Nitric OxideInnate Immune SystemImmunologyPathologyCell Death +15

Rhodium(II) Proximity‐Labeling Identifies a Novel Target Site on STAT3 for Inhibitors with Potent Anti‐Leukemia Activity

Matthew B. Minus, Wei Liu, Farrukh Vohidov, +9

Angewandte Chemie International Edition

Synthetic and Biological Studies of Phaeosphaerides

Anthoula Chatzimpaloglou, Mikhail Kolosov, T. Kris Eckols, +2

The Journal of Organic Chemistry

Signal TransductionSignaling PathwayBiochemistryBiochemical TaxonomyStat3 Dimerization +11

Novel STAT3 small-molecule inhibitors identified by structure-based virtual ligand screening incorporating SH2 domain flexibility

Ren Kong, Uddalak Bharadwaj, T. Kris Eckols, +9

Pharmacological Research

Medicinal ChemistryNatural SciencesStructure-based Virtual LigandMedicinePharmacology +8

Monoclonal Antibodies Specific for STAT3β Reveal Its Contribution to Constitutive STAT3 Phosphorylation in Breast Cancer

Uddalak Bharadwaj, Moses M. Kasembeli, T. Kris Eckols, +5

Cancers

Monoclonal Antibodies SpecificBreast OncologyStat3β HomodimersImmunologyImmune Regulation +18

Targeting STAT3 anti-apoptosis pathways with organic and hybrid organic–inorganic inhibitors

Matthew B. Minus, Haopei Wang, Jaime O. Munoz, +10

Organic & Biomolecular Chemistry