Small-molecule targeting of signal transducer and activator of transcription (STAT) 3 to treat non-small cell lung cancer

Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas

Sizhi Paul Gao, Kevin G. Mark, Kenneth Leslie et al. · Journal of Clinical Investigation · 2007 · 664 citations · Full text

Medicine, Cancer Biology, Oncology +17

Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro.

Jennifer R. Grandis, Stephanie D. Drenning, Anutosh Chakraborty et al. · Journal of Clinical Investigation · 1998 · 508 citations · Full text

Life Sciences, Cancer Biology, Molecular Biology +13

Roles of STAT3 and ZEB1 Proteins in E-cadherin Down-regulation and Human Colorectal Cancer Epithelial-Mesenchymal Transition

Hua Xiong, Jie Hong, Wan Du et al. · Journal of Biological Chemistry · 2011 · 314 citations · Full text

Medicine, Molecular Biology, Oncology +16

Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor

Michele S. Redell, Marcos J. Ruiz, Todd A. Alonzo et al. · Blood · 2011 · 263 citations · Full text

Life Sciences, Oncology, Pharmacology +17

Stat3 Activation Links a C/EBPδ to Myostatin Pathway to Stimulate Loss of Muscle Mass

Jenny S. Pan, Yanjun Dong, David J. Tweardy et al. · Cell Metabolism · 2013 · 259 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14