Concepedia

Stat3 Signaling

Stat3 Signaling is a intracellular signaling pathway that mediates cytokine- and growth factor-induced gene transcription through the activation and dimerization of the signal transducer and activator of transcription 3 (Stat3) protein, distinguishing it from other Stat family members by its specific role in promoting mammary epithelial cell apoptosis and tissue remodeling during mammary gland involution.

8.4K

Publications

593.7K

Citations

49.7K

Authors

5.1K

Institutions

Publications per year

2017–2026

3.5K

Variants

Signal Transducer And Activator Of Transcription 3 SignalingStat3 Signaling Pathway

Parents

Publications

8.4K

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

Sergei I. Grivennikov, Eliad Karin, Janoš Terzić et al. · Cancer Cell · 2009 · 2.1K citations · Full text

, , +16

BMP Induction of Id Proteins Suppresses Differentiation and Sustains Embryonic Stem Cell Self-Renewal in Collaboration with STAT3

Qi-Long Ying, Jennifer Nichols, Ian Chambers et al. · Cell · 2003 · 2.1K citations · Full text

, , +15

Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6

Zhong Zhong, Zilong Wen, James Darnell · Science · 1994 · 2.1K citations

, , +14

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

Zilong Wen, Zhong Zhong, James Darnell · Cell · 1995 · 2K citations · Full text

, , +10

Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells

Robyn Catlett-Falcone, Terry H. Landowski, Marc M. Oshiro et al. · Immunity · 1999 · 1.7K citations · Full text

, , +16

1–5 of 8.4K

Authors

49.7K

  1. RJ
    Richard Jove

    Moffitt Cancer Center, United States

    79 publications · 23.8K citations

    63

    h-index

  2. HY
    Hua Yu

    City of Hope, United States

    55 publications · 14.1K citations

    45

    h-index

  3. JL
    Jiayuh Lin

    The Ohio State University, United States

    73 publications · 5.8K citations

    45

    h-index

  4. JT
    James Turkson

    University of Central Florida, United States

    51 publications · 11.9K citations

    37

    h-index

  5. DJ
    David J. Tweardy

    Baylor College of Medicine, United States

    56 publications · 4.5K citations

    37

    h-index

1–5 of 49.7K

Institutions

5.1K

  1. The University of Texas MD Anderson Cancer Center

    Houston, United States

    90 h-index

    1.3K publications

    149.7K citations

  2. Harvard University

    Cambridge, United States

    71 h-index

    581 publications

    80.5K citations

  3. Inserm

    Paris, France

    68 h-index

    1K publications

    92.7K citations

  4. The University of Osaka

    Osaka, Japan

    68 h-index

    634 publications

    93.8K citations

  5. National Institutes of Health

    Bethesda, United States

    64 h-index

    559 publications

    59.2K citations

  6. National University of Singapore

    Singapore, Singapore

    58 h-index

    377 publications

    36.4K citations

  7. Moffitt Cancer Center

    Tampa, United States

    58 h-index

    347 publications

    126.1K citations

  8. Shanghai Jiao Tong University

    Shanghai, China

    55 h-index

    864 publications

    52.5K citations

1–8 of 5.1K

Venues

  1. Journal of Biological Chemistry

    JBC · 315 publications · 33.4K citations

    101

    h-index

  2. Cancer Research

    171 publications · 19.9K citations

    89

    h-index

  3. The Journal of Immunology

    JI · 189 publications · 22.3K citations

    83

    h-index

  4. Oncogene

    158 publications · 20.6K citations

    81

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 107 publications · 21.9K citations

    77

    h-index

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