Brian Aquila

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

Adriana E. Tron, Matthew A. Belmonte, Ammar Adam et al. · Nature Communications · 2018 · 486 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Photoredox Mediated Nickel Catalyzed Cross-Coupling of Thiols With Aryl and Heteroaryl Iodides via Thiyl Radicals

Martins S. Oderinde, Mathieu Frenette, Daniel Robbins et al. · Journal of the American Chemical Society · 2016 · 453 citations

Natural Sciences, Chemistry, Catalysis +15

Highly Chemoselective Iridium Photoredox and Nickel Catalysis for the Cross‐Coupling of Primary Aryl Amines with Aryl Halides

Martins S. Oderinde, Natalie H. Jones, Antoine Juneau et al. · Angewandte Chemie International Edition · 2016 · 211 citations

Natural Sciences, Chemistry, Medicinal Chemistry +17

Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain

Gizem Akçay, Matthew A. Belmonte, Brian Aquila et al. · Nature Chemical Biology · 2016 · 194 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

A study of the reactivity of S^(VI)–F containing warheads with nucleophilic amino-acid side chains under physiological conditions

H. G. MUKHERJEE, J.E. Debreczeni, J. Breed et al. · Organic & Biomolecular Chemistry · 2017 · 165 citations

Pharmacy, Biochemistry, Medicinal Chemistry +12