Inhibition of HIV-1 Ribonuclease H by a Novel Diketo Acid, 4-[5-(Benzoylamino)thien-2-yl]-2,4-dioxobutanoic Acid

Cathryn A. Shaw-Reid, Vandna Munshi, Pia Graham, +10

Journal of Biological Chemistry

Discovery of 3-{5-[(6-Amino-1<i>H</i>-pyrazolo[3,4-<i>b</i>]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): A Potent, Orally Bioavailable HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor with Improved Potency against Key Mutant Viruses

Thomas J. Tucker, John T. Sisko, Robert M. Tynebor, +18

Journal of Medicinal Chemistry

Molecular BiologyKey Mutant VirusesPharmacotherapyAntiviral DrugPhysical Properties +18

Tetrazole thioacetanilides: Potent non-nucleoside inhibitors of WT HIV reverse transcriptase and its K103N mutant

Ester Muraglia, Olaf Kinzel, Ralph Laufer, +9

Bioorganic & Medicinal Chemistry Letters

MedicineNatural SciencesHuman RetrovirusAntiviral Drug DevelopmentMolecular Biology +10

Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs)

Zhijian Zhao, S. E. Wolkenberg, Meiqing Lu, +15

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryNovel Indole-3-sulfonamidesDrug DiscoveryMedicineNatural Sciences +9

Dissecting the Effects of DNA Polymerase and Ribonuclease H Inhibitor Combinations on HIV-1 Reverse-Transcriptase Activities

Cathryn A. Shaw-Reid, Bradley P. Feuston, Vandna Munshi, +6

Biochemistry

Viral ReplicationImmunologyMolecular BiologyHiv-1 Reverse-transcriptase ActivitiesAntiviral Drug +16

Design, Synthesis, and X-ray Crystallographic Analysis of a Novel Class of HIV-1 Protease Inhibitors

Ashit K. Ganguly, S. Alluri, D. Caroccia, +10

Journal of Medicinal Chemistry

The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations

Thomas J. Tucker, Sandeep Saggar, John T. Sisko, +18

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineNatural SciencesAntiviral Drug DevelopmentAntiviral Therapy +10

Maximizing Diversity from a Kinase Screen: Identification of Novel and Selective pan-Trk Inhibitors for Chronic Pain

Shawn J. Stachel, John M. Sanders, Darrell A. Henze, +22

Journal of Medicinal Chemistry

Small Molecule InhibitorsDrug TargetPain MedicineMolecular PainPharmacotherapy +20

Design and Synthesis of Conformationally Constrained Inhibitors of Non-Nucleoside Reverse Transcriptase

Robert Gomez, Samson J. Jolly, Theresa M. Williams, +16

Journal of Medicinal Chemistry

Molecular BiologyPharmacotherapyAntiviral DrugChemical BiologyNon-nucleoside Reverse Transcriptase +20

Substituted tetrahydroquinolines as potent allosteric inhibitors of reverse transcriptase and its key mutants

Dai‐Shi Su, John J. Lim, Elizabeth Tinney, +23

Bioorganic & Medicinal Chemistry Letters

BiochemistryMedicineDrug DiscoveryReverse TranscriptasePotent Allosteric Inhibitors +5