Discovery of Raltegravir, a Potent, Selective Orally Bioavailable HIV-Integrase Inhibitor for the Treatment of HIV-AIDS Infection

Vincenzo Summa, Alessia Petrocchi, Fabio Bonelli, +20

Journal of Medicinal Chemistry

Antiviral DrugMedicinal ChemistryAntiviral Drug DevelopmentResistance Mutation (Virology)Biochemistry +14

Response of melanocortin–4 receptor–deficient mice to anorectic and orexigenic peptides

Donald J. Marsh, Gunther Hollopeter, Dennis Huszar, +5

Nature Genetics

NeuropeptidesAppetite ControlMedicinePhysiologyImmunology +7

Efficient and regulated erythropoietin production by naked DNA injection and muscle electroporation

Gabriella Rizzuto, Manuela Cappelletti, Domenico Maione, +9

Proceedings of the National Academy of Sciences

Regenerative MedicineNaked Dna InjectionLow-voltage Electric PulsesXenotransplantationEngineering +13

Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance

Isabelle Gloaguen, Patrizia Costa, Anna Demartis, +10

Proceedings of the National Academy of Sciences

Metabolic DisorderFunctional LeptinInsulin SignalingObesityMetabolic Syndrome +17

Laquinimod arrests experimental autoimmune encephalomyelitis by activating the aryl hydrocarbon receptor

Joel Kaye, Victor Piryatinsky, Tal Birnberg, +16

Proceedings of the National Academy of Sciences

Behavioural effects of receptor-specific substance P agonists

Dalia Papir-Kricheli, Joseph M. Frey, Ralph Laufer, +4

Pain

Enhancing B- and T-Cell Immune Response to a Hepatitis C Virus E2 DNA Vaccine by Intramuscular Electrical Gene Transfer

S. Zucchelli, Stefania Capone, Elena Fattori, +8

Journal of Virology

ImmunologyViral PathogenesisImmunotherapyViral HepatitisT-cell Immune Response +14

4,5-Dihydroxypyrimidine Carboxamides and <i>N</i>-Alkyl-5-hydroxypyrimidinone Carboxamides Are Potent, Selective HIV Integrase Inhibitors with Good Pharmacokinetic Profiles in Preclinical Species

Vincenzo Summa, Alessia Petrocchi, Victor G. Matassa, +7

Journal of Medicinal Chemistry

Bioorganic ChemistryPharmacotherapyAntiviral DrugMedicinal Chemistry4,5-Dihydroxypyrimidine Carboxamides +15

HCV NS5b RNA-Dependent RNA Polymerase Inhibitors:  From α,γ-Diketoacids to 4,5-Dihydroxypyrimidine- or 3-Methyl-5- hydroxypyrimidinonecarboxylic Acids. Design and Synthesis

Vincenzo Summa, Alessia Petrocchi, Victor G. Matassa, +5

Journal of Medicinal Chemistry

Viral Polymerase StructureMolecular BiologyAntiviral DrugChemical BiologyMedicinal Chemistry +14

Tetrazole thioacetanilides: Potent non-nucleoside inhibitors of WT HIV reverse transcriptase and its K103N mutant

Ester Muraglia, Olaf Kinzel, Ralph Laufer, +9

Bioorganic & Medicinal Chemistry Letters

MedicineNatural SciencesHuman RetrovirusAntiviral Drug DevelopmentMolecular Biology +10