Robert M. Tynebor

Discovery of 3-{5-[(6-Amino-1<i>H</i>-pyrazolo[3,4-<i>b</i>]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): A Potent, Orally Bioavailable HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor with Improved Potency against Key Mutant Viruses

Thomas J. Tucker, John T. Sisko, Robert M. Tynebor et al. · Journal of Medicinal Chemistry · 2008 · 133 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Mechanism based neurotoxicity of mGlu5 positive allosteric modulators – Development challenges for a promising novel antipsychotic target

Sophie Parmentier‐Batteur, Peter H. Hutson, Karsten Menzel et al. · Neuropharmacology · 2013 · 94 citations

Medicine, Neuroscience, Pharmacology +15

The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations

Thomas J. Tucker, Sandeep Saggar, John T. Sisko et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 61 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Distinct Mutation Pathways of Non-Subtype B HIV-1 during<i>In Vitro</i>Resistance Selection with Nonnucleoside Reverse Transcriptase Inhibitors

Ming‐Tain Lai, Meiqing Lu, Peter J. Felock et al. · Antimicrobial Agents and Chemotherapy · 2010 · 38 citations · Full text

Life Sciences, Infectious Diseases, Microbiology +17

Antiviral Activity of MK-4965, a Novel Nonnucleoside Reverse Transcriptase Inhibitor

Ming‐Tain Lai, Vandna Munshi, Sinoeun Touch et al. · Antimicrobial Agents and Chemotherapy · 2009 · 37 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17