M. Katharine Holloway

Author

Also Known As

M Katharine Holloway, M. Holloway, M. K. HOLLOWAY, M. KATHARINE HOLLOWAY, M. Katharine Holloway, M.K. Holloway, M.Katharine Holloway, Marcus Holloway, Mia K. Holloway, Timothy Allison

Publications

Citations

H-Index

Concepts

All Affiliations

United States Military Academy Merck & Co., Inc., Rahway, NJ, USA (United States)WuXi AppTec (China)

About

M. Katharine Holloway is an author at United States Military Academy specializing in medicine, natural sciences, and drug discovery.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	26	34	2.8K
2	Natural Sciences	22	29	2.1K
3	Biochemistry	22	28	2K
4	Engineering	2	2	78
5	Social Sciences	2	2	28

M. Katharine Holloway

Publications

3.7K

Citations

H-Index

Page 1

	Year	Citations
A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase Daria J. Hazuda, Neville J. Anthony, Robert Gomez, Proceedings of the National Academy of Sciences Hiv-1 IntegraseImmunologyCell CulturePharmacotherapyAntiviral Drug	2004	332
Structure-Based Design of Potent and Selective Cell-Permeable Inhibitors of Human β-Secretase (BACE-1) Shawn J. Stachel, Craig A. Coburn, Thomas G. Steele, Journal of Medicinal Chemistry Protein SecretionDrug TargetCell CultureProtein PurificationHuman β-Secretase	2004	273
A priori prediction of activity for HIV-1 protease inhibitors employing energy minimization in the active site M. Katharine Holloway, Jenny Wai, Thomas A. Halgren, Journal of Medicinal Chemistry Molecular BiologyAntiviral DrugEnergy MinimizationForce FieldAntiviral Drug Development	1995	228
Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor Steven J. Harper, John A. McCauley, Michael T. Rudd, ACS Medicinal Chemistry Letters ImmunologyMolecular BiologyPharmacotherapyAntiviral DrugMedicinal Chemistry	2012	201
4-Aryl-2,4-dioxobutanoic Acid Inhibitors of HIV-1 Integrase and Viral Replication in Cells John Wai, Melissa S. Egbertson, Linda S. Payne, Journal of Medicinal Chemistry Hiv-1 IntegraseViral ReplicationImmunologyAltmetric Attention ScoreCell Culture	2000	187
Discovery of Vaniprevir (MK-7009), a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor John A. McCauley, Charles McIntyre, Michael T. Rudd, Journal of Medicinal Chemistry ImmunologyAntiviral DrugMedicinal ChemistryViral HepatitisAntiviral Drug Development	2010	176
Synthesis and antiviral activity of a series of HIV-1 protease inhibitors with functionality tethered to the P1 or P1' phenyl design Wayne J. Thompson, Paula M.D. Fitzgerald, M. Katharine Holloway, Journal of Medicinal Chemistry	1992	167
Thermodynamics of Ligand Binding and Efficiency Charles H. Reynolds, M. Katharine Holloway ACS Medicinal Chemistry Letters	2011	157
Molecular Modeling Based Approach to Potent P2−P4 Macrocyclic Inhibitors of Hepatitis C NS3/4A Protease Nigel J. Liverton, M. Katharine Holloway, John A. McCauley, Journal of the American Chemical Society Molecular DockingMedicinal ChemistryInitial CompoundsAntiviral CompoundBiochemistry	2008	134
Drug-like Density: A Method of Quantifying the “Bindability” of a Protein Target Based on a Very Large Set of Pockets and Drug-like Ligands from the Protein Data Bank Robert P. Sheridan, Vladimir N. Maiorov, M. Katharine Holloway, Journal of Chemical Information and Modeling	2010	129

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