Nature Biotechnology · 2017 · 470 citations · 22 references
EngineeringBioengineeringMolecular BiologyProtein EngineeringProtein DesignPam MatricesPam Sequence RecognitionPam Specificity EngineeringPam-dependent Specificity
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Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System
Bernd Zetsche, Jonathan S. Gootenberg, Omar O. Abudayyeh et al. · Cell · 2015 · 4.9K citations · Full text
In vivo genome editing using Staphylococcus aureus Cas9
F. Ann Ran, Le Cong, Winston X. Yan et al. · Nature · 2015 · 2.7K citations · Full text
High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
Benjamin P. Kleinstiver, Vikram Pattanayak, Michelle S. Prew et al. · Nature · 2016 · 2.7K citations · Full text
Rationally engineered Cas9 nucleases with improved specificity
Ian M. Slaymaker, Linyi Gao, Bernd Zetsche et al. · Science · 2015 · 2.5K citations
RNA-guided editing of bacterial genomes using CRISPR-Cas systems
Wenyan Jiang, David Bikard, David Cox et al. · Nature Biotechnology · 2013 · 2.5K citations