Multiplex Genome Engineering Using CRISPR/Cas Systems

Le Cong, F. Ann Ran, David Cox, +8

Science

Single Crispr ArrayEngineeringShort RnasGeneticsSynthetic Biology +10

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

Stefano Romeo, Julia Kozlitina, Chao Xing, +6

Nature Genetics

Metabolic SyndromeHepatologyGeneticsLiver PhysiologyGenetic Epidemiology +11

RNA-guided editing of bacterial genomes using CRISPR-Cas systems

Wenyan Jiang, David Bikard, David Cox, +2

Nature Biotechnology

Crispr-cas SystemsGenetic EngineeringMolecular BiologyGene EditingGenome Editing +3

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

Omar O. Abudayyeh, Jonathan S. Gootenberg, Silvana Konermann, +12

Science

RNA targeting with CRISPR–Cas13

Omar O. Abudayyeh, Jonathan S. Gootenberg, Patrick Essletzbichler, +11

Nature

Gene EditingGenome EditingGene ExpressionMedicineCell Biology +1

RNA editing with CRISPR-Cas13

David Cox, Jonathan S. Gootenberg, Omar O. Abudayyeh, +4

Science

EngineeringGenome SurgeryRna Type 2Novel TherapyMedicine +13

Large-scale association analysis identifies new risk loci for coronary artery disease

Panos Deloukas, Stavroula Kanoni, Christina Willenborg, +173

Nature Genetics

Genome-wide Association StudyLarge-scale Association AnalysisEpidemiologyCardiovascular EpidemiologyCardiovascular Disease +11

Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15

Roel Nusse, Albert van Ooyen, David Cox, +2

Nature

ImmunogeneticsMouse Chromosome 15ImmunologyPutative Mammary OncogeneProviral Activation +5

Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28

Aaron A. Smargon, David Cox, Neena Pyzocha, +9

Molecular Cell

Natural SciencesAccessory Proteins Csx27Rna BiologyMolecular BiologyGene Editing +5

Engineered Cpf1 variants with altered PAM specificities

Linyi Gao, David Cox, Winston X. Yan, +7

Nature Biotechnology

Engineered Cpf1 VariantsSignal TransductionEngineeringProtein AssemblyProtein Function +5