DNA targeting specificity of RNA-guided Cas9 nucleases

Patrick D. Hsu, David A. Scott, Joshua A. Weinstein, +11

Nature Biotechnology

Molecular BiologyGene EditingGenome EditingRna-guided Cas9 NucleasesMedicine +1

Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity

F. Ann Ran, Patrick D. Hsu, Chie-Yu Lin, +8

Cell

Rna-guided Crispr Cas9GeneticsMolecular BiologyGenetic EngineeringGene Editing +5

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

Silvana Konermann, Mark D. Brigham, Alexandro E. Trevino, +9

Nature

Engineered Crispr-cas9 ComplexTranscriptional RegulationNatural SciencesGenetic EngineeringMolecular Biology +6

Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

Hiroshi Nishimasu, F. Ann Ran, Patrick D. Hsu, +6

Cell

ChromatinTarget DnaCrystal StructureGuide RnaNatural Sciences +10

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

Omar O. Abudayyeh, Jonathan S. Gootenberg, Silvana Konermann, +12

Science

Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening

Julia Joung, Silvana Konermann, Jonathan S. Gootenberg, +5

Nature Protocols

GeneticsGenetic EngineeringGene EditingGenome EditingGenome-scale Crispr-cas9 Knockout +3

Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems

Sergey Shmakov, Omar O. Abudayyeh, Kira S. Makarova, +9

Molecular Cell

Off-target EffectFunctional GenomicsEngineeringCrispr-cas SystemsMolecular Biology +9

Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors

Silvana Konermann, Peter Lotfy, Nicholas J. Brideau, +3

Cell

Transcriptome EngineeringGenetic EngineeringMolecular BiologyGene EditingGenome Editing +3

Optical control of mammalian endogenous transcription and epigenetic states

Silvana Konermann, Mark D. Brigham, Alexandro E. Trevino, +7

Nature

Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

Hiroshi Nishimasu, Naoshi Dohmae, Ryuichiro Ishitani, +6

DSpace@MIT (Massachusetts Institute of Technology)

ChromatinTarget DnaCrystal StructureGuide RnaNatural Sciences +10