RNA-guided editing of bacterial genomes using CRISPR-Cas systems

Wenyan Jiang, David Bikard, David Cox, +2

Nature Biotechnology

Crispr-cas SystemsGenetic EngineeringMolecular BiologyGene EditingGenome Editing +3

Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system

David Bikard, Wenyan Jiang, Poulami Samai, +3

Nucleic Acids Research

EngineeringMolecular BiologyOmega SubunitCrisprOff-target Effect +17

Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials

David Bikard, Chad W. Euler, Wenyan Jiang, +5

Nature Biotechnology

EngineeringSynthetic BiologyGenetic EngineeringMolecular BiologyGene Editing +5

PhageTerm: a tool for fast and accurate determination of phage termini and packaging mechanism using next-generation sequencing data

Julian R. Garneau, Florence Depardieu, Louis‐Charles Fortier, +2

Scientific Reports

Cas9 specifies functional viral targets during CRISPR–Cas adaptation

Robert Heler, Poulami Samai, Joshua W. Modell, +4

Nature

Crispr–cas AdaptationGene EditingGenome EditingSystems BiologyMedicine +1

Phages and their satellites encode hotspots of antiviral systems

François Rousset, Florence Depardieu, Solange Miele, +6

Cell Host & Microbe

CRISPR Interference Can Prevent Natural Transformation and Virulence Acquisition during In Vivo Bacterial Infection

David Bikard, Asma Hatoum-Aslan, Daniel Mucida, +1

Cell Host & Microbe

Virulence AcquisitionVirulence FactorPathogenesisGenetic EngineeringVivo Bacterial Infection +8

Conditional tolerance of temperate phages via transcription-dependent CRISPR-Cas targeting

Gregory W. Goldberg, Wenyan Jiang, David Bikard, +1

Nature

GeneticsGenetic EngineeringConditional ToleranceGene EditingGenome Editing +4

Conjugative DNA Transfer Induces the Bacterial SOS Response and Promotes Antibiotic Resistance Development through Integron Activation

Zeynep Baharoglu, David Bikard, Didier Mazel

PLoS Genetics

GeneticsMolecular BiologyCassette RearrangementsAntibiotic ResistanceConjugative Elements +15

A CRISPRi screen in E. coli reveals sequence-specific toxicity of dCas9

Lun Cui, A. Vigouroux, François Rousset, +3

Nature Communications