Concepedia

Pam Sequence Recognition

PAM Sequence Recognition is a molecular targeting mechanism in CRISPR-Cas systems that identifies a short, specific DNA sequence adjacent to the target site, distinguishing it from other genomic sequences to ensure precise Cas nuclease binding and cleavage.

235

Publications

28.1K

Citations

1.3K

Authors

430

Institutions

Publications per year

2017–2026

182

Parents

Publications

235

Engineered CRISPR-Cas9 nucleases with altered PAM specificities

Benjamin P. Kleinstiver, Michelle S. Prew, Shengdar Q. Tsai et al. · Nature · 2015 · 1.7K citations · Full text

, , +13

Evolved Cas9 variants with broad PAM compatibility and high DNA specificity

Johnny H. Hu, Shannon M. Miller, Maarten H. Geurts et al. · Nature · 2018 · 1.6K citations

, , +12

Short motif sequences determine the targets of the prokaryotic CRISPR defence system

Francisco J. M. Mojica, César Díez‐Villaseñor, Jesús García‐Martínez et al. · Microbiology · 2009 · 1.6K citations

, , +13

Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease

Carolin Anders, Ole Niewoehner, A. Duerst et al. · Nature · 2014 · 1.4K citations

, , +13

Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants

Russell T. Walton, Kathleen A. Christie, Madelynn N. Whittaker et al. · Science · 2020 · 1.3K citations · Full text

, , +15

1–5 of 235

Authors

1.3K

  1. KS
    Konstantin Severinov

    Rutgers, The State University of New Jersey, United States

    8 publications · 532 citations

    8

    h-index

  2. VŠ
    Virginijus Šikšnys

    Vilnius University, Lithuania

    7 publications · 1.6K citations

    7

    h-index

  3. BP
    Benjamin P. Kleinstiver

    Massachusetts General Hospital, United States

    7 publications · 3.7K citations

    7

    h-index

  4. SJ
    Stan J. J. Brouns

    Delft University of Technology, Netherlands

    7 publications · 922 citations

    7

    h-index

  5. ON
    Osamu Nureki

    The University of Tokyo, Japan

    6 publications · 2.2K citations

    6

    h-index

1–5 of 1.3K

Institutions

430

  1. Chinese Academy of Sciences

    Beijing, China

    15 h-index

    52 publications

    4.5K citations

  2. Massachusetts Institute of Technology

    Cambridge, United States

    13 h-index

    43 publications

    11.2K citations

  3. Harvard University

    Cambridge, United States

    13 h-index

    46 publications

    30.3K citations

  4. University of Chinese Academy of Sciences

    Beijing, China

    10 h-index

    23 publications

    1.9K citations

  5. Broad Institute

    Cambridge, United States

    9 h-index

    44 publications

    31.8K citations

  6. Wageningen University & Research

    Wageningen, The Netherlands

    8 h-index

    19 publications

    1.6K citations

  7. Zhejiang University

    Hangzhou, China

    8 h-index

    11 publications

    905 citations

  8. Tsinghua University

    Beijing, China

    7 h-index

    33 publications

    1.3K citations

1–8 of 430

Venues

  1. Nature Communications

    25 publications · 1.9K citations

    24

    h-index

  2. Nucleic Acids Research

    36 publications · 2.5K citations

    24

    h-index

  3. Molecular Cell

    10 publications · 1.6K citations

    10

    h-index

  4. Journal of Biological Chemistry

    JBC · 9 publications · 598 citations

    9

    h-index

  5. RNA Biology

    5 publications · 1K citations

    5

    h-index

1–5