Shengdar Q. Tsai

Efficient genome editing in zebrafish using a CRISPR-Cas system

Woong Y. Hwang, Yanfang Fu, Deepak Reyon et al. · Nature Biotechnology · 2013 · 3K citations · Full text

Genome Surgery, Genetics, Efficient Genome Editing +5

High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects

Benjamin P. Kleinstiver, Vikram Pattanayak, Michelle S. Prew et al. · Nature · 2016 · 2.6K citations · Full text

Natural Sciences, Genetic Engineering, Molecular Biology +7

GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

Shengdar Q. Tsai, Zongli Zheng, Nathalie T. Nguyen et al. · Nature Biotechnology · 2014 · 2.2K citations · Full text

Off-target Effect, Genetics, Gene Editing +7

Engineered CRISPR-Cas9 nucleases with altered PAM specificities

Benjamin P. Kleinstiver, Michelle S. Prew, Shengdar Q. Tsai et al. · Nature · 2015 · 1.6K citations · Full text

Engineering, Synthetic Biology, Genetic Engineering +8

FLASH assembly of TALENs for high-throughput genome editing

Deepak Reyon, Shengdar Q. Tsai, Cyd Khayter et al. · Nature Biotechnology · 2012 · 1.2K citations · Full text

Engineering, Genome Surgery, Synthetic Biology +8