Zongli Zheng

High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects

Benjamin P. Kleinstiver, Vikram Pattanayak, Michelle S. Prew et al. · Nature · 2016 · 2.6K citations · Full text

Natural Sciences, Genetic Engineering, Molecular Biology +7

GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

Shengdar Q. Tsai, Zongli Zheng, Nathalie T. Nguyen et al. · Nature Biotechnology · 2014 · 2.2K citations · Full text

Off-target Effect, Genetics, Gene Editing +7

Crizotinib in <i>ROS1</i>-Rearranged Non–Small-Cell Lung Cancer

Alice T. Shaw, Sai‐Hong Ignatius Ou, Yung‐Jue Bang et al. · New England Journal of Medicine · 2014 · 2K citations · Full text

Engineered CRISPR-Cas9 nucleases with altered PAM specificities

Benjamin P. Kleinstiver, Michelle S. Prew, Shengdar Q. Tsai et al. · Nature · 2015 · 1.6K citations · Full text

Engineering, Synthetic Biology, Genetic Engineering +8

A Pyrosequencing Study in Twins Shows That Gastrointestinal Microbial Profiles Vary With Inflammatory Bowel Disease Phenotypes

Benjamin P. Willing, Johan Dicksved, Jonas Halfvarson et al. · Gastroenterology · 2010 · 1K citations · Full text

Dysbiosis, Gut Microbiology, Gastroenterology +8