Nature · 2015 · 1.7K citations · 34 references
Life SciencesGeneticsMolecular BiologyGenetic EngineeringGenome EditingGenome EngineeringCrispr-based EngineeringCrispr-cas SystemsGuide Rna DesignTarget Site SelectionTherapeutic Genome EditingCas Nuclease CleavageCas Nuclease EngineeringCas Nuclease SpecificityPam Sequence RecognitionPam Specificity Engineering
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Fast and accurate short read alignment with Burrows–Wheeler transform
Heng Li, Richard Durbin · Bioinformatics · 2009 · 62.8K citations · Full text
Initial sequencing and analysis of the human genome
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A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
Martin Jínek, Krzysztof Chylinski, Ines Fonfara et al. · Science · 2012 · 17.3K citations · Full text
Multiplex Genome Engineering Using CRISPR/Cas Systems
Le Cong, F. Ann Ran, David Cox et al. · Science · 2013 · 15.7K citations
RNA-Guided Human Genome Engineering via Cas9
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