A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

Martin Jínek, Krzysztof Chylinski, Ines Fonfara, +3

Science

Crispr RnasAdaptive Bacterial ImmunityCrispr-associated Protein Cas9MedicineGenetics +13

RNA-programmed genome editing in human cells

Martin Jínek, Alexandra East, Aaron Cheng, +3

eLife

Off-target EffectHybrid Guide RnasGuide RnaNatural SciencesImmunology +11

DNA interrogation by the CRISPR RNA-guided endonuclease Cas9

Samuel H. Sternberg, Sy Redding, Martin Jínek, +2

Nature

Genetic EngineeringMolecular BiologyGene EditingGenome EditingMedicine +2

Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease

Carolin Anders, Ole Niewoehner, A. Duerst, +1

Nature

BiochemistryStructural BioinformaticsNatural SciencesCas9 EndonucleaseDna Analysis +9

Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation

Martin Jínek, Fuguo Jiang, David W. Taylor, +12

Science

Type Ii CrisprRna ProcessingSystems BiologyMedicineNatural Sciences +13

Sequence- and Structure-Specific RNA Processing by a CRISPR Endonuclease

R.E. Haurwitz, Martin Jínek, Blake Wiedenheft, +2

Science

Crystal StructureCrispr LocusRna Structure PredictionGenetic EngineeringMolecular Biology +10

A prudent path forward for genomic engineering and germline gene modification

David Baltimore, Paul Berg, Michael Botchan, +15

Science

EngineeringGeneticsMolecular BiologySynthetic CircuitGenomics +19

Structural Basis for Guide RNA Processing and Seed-Dependent DNA Targeting by CRISPR-Cas12a

Daan C. Swarts, John van der Oost, Martin Jínek

Molecular Cell

Rna ProcessingSeed-dependent Dna TargetingEngineeringGenetic EngineeringMolecular Biology +9

Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a

Daan C. Swarts, Martin Jínek

Molecular Cell

Nucleic Acid ChemistryOligonucleotideMolecular BiologyMechanistic InsightsTrans-acting Dnase Activities +2

Structural insights into the molecular mechanism of the m6A writer complex

P. Sledz, Martin Jínek

eLife

Crystal StructureEngineeringMolecular BiologyHuman MEpigenetics +19