Investigation of the structural requirements of K-Ras(G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

J.M. Ostrem, Ulf Peters, Martin L. Sos et al. · Nature · 2013 · 2.5K citations · Full text

Life Sciences, Molecular Biology, Pharmacology +14

Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State

Matthew P. Patricelli, Matthew R. Janes, Lian‐Sheng Li et al. · Cancer Discovery · 2016 · 754 citations · Full text

Medicine, Medicinal Chemistry, Oncology +17

Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling

Gunther Zimmermann, Bjoern Papke, Shehab Ismail et al. · Nature · 2013 · 598 citations

Life Sciences, Molecular Biology, Molecular Genetics +12

Discovery of Small Molecules that Bind to K‐Ras and Inhibit Sos‐Mediated Activation

Qi Sun, Jason P. Burke, Jason Phan et al. · Angewandte Chemie International Edition · 2012 · 499 citations

Life Sciences, Molecular Biology, Pharmacology +15

In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C

John C. Hunter, Deepak Gurbani, Scott B. Ficarro et al. · Proceedings of the National Academy of Sciences · 2014 · 245 citations · Full text

Medicine, Molecular Biology, Oncology +14