Remarkable ligand effect on the enantioselectivity of the chiral lanthanum complex-catalyzed asymmetric epoxidation of enones

Kazuhiro Daikai, Masahiro Kamaura, Junji Inanaga

Tetrahedron Letters

Chemical EngineeringEngineeringOrganic ChemistryCatalysisStereoselective Synthesis +4

K-Ras(G12D)-selective inhibitory peptides generated by random peptide T7 phage display technology

Kotaro Sakamoto, Yusuke Kamada, Tomoya Sameshima, +9

Biochemical and Biophysical Research Communications

BiochemistryMedicineNatural SciencesPeptide EngineeringPeptide Library +7

Crystal Structure of a Human K-Ras G12D Mutant in Complex with GDP and the Cyclic Inhibitory Peptide KRpep-2d

Satoshi Sogabe, Yusuke Kamada, Masanori Miwa, +7

ACS Medicinal Chemistry Letters

Crystal StructureProtein AssemblyMolecular BiologyCell DifferentiationCancer Biology +16

Investigation of the structural requirements of K-Ras(G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging

Ayumu Niida, Shigekazu Sasaki, Kazuko Yonemori, +5

Bioorganic & Medicinal Chemistry Letters

Alanine ScansMedicinal ChemistryBiochemistryStructural RequirementsNatural Sciences +8

Discovery and Structure–Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials

Benoı̂t Laleu, Yuichiro Akao, Atsuko Ochida, +18

Journal of Medicinal Chemistry

Melanin-Concentrating Hormone Receptor 1 Antagonists. Synthesis and Structure–Activity Relationships of Novel 3-(Aminomethyl)quinolines

Makoto Kamata, Toshiro Yamashita, Toshihiro Imaeda, +17

Journal of Medicinal Chemistry

Discovery of a Novel Series of<i>N</i>-Phenylindoline-5-sulfonamide Derivatives as Potent, Selective, and Orally Bioavailable Acyl CoA:Monoacylglycerol Acyltransferase-2 Inhibitors

Kenjiro Sato, Hiroki Takahagi, Takeshi Yoshikawa, +13

Journal of Medicinal Chemistry

Discovery of a novel series of indoline carbamate and indolinylpyrimidine derivatives as potent GPR119 agonists

Kenjiro Sato, Hiromichi Sugimoto, Kentaro Rikimaru, +7

Bioorganic & Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryBiochemistryFunctional SelectivityMedicine +9

Second-Generation AUTACs for Targeted Autophagic Degradation

Daiki Takahashi, Taiichi Ora, Shigekazu Sasaki, +11

Journal of Medicinal Chemistry

Targeted Autophagic DegradationMitophagyMolecular BiologyPeptide ScienceChemical Biology +20

Discovery and characterization of selective human sphingomyelin synthase 2 inhibitors

Ryutaro Adachi, Kazumasa Ogawa, Shin-ichi Matsumoto, +7

European Journal of Medicinal Chemistry

Medicinal ChemistryBiochemistryNatural SciencesMedicineMechanism Of Action +4