Kotaro Sakamoto

K-Ras(G12D)-selective inhibitory peptides generated by random peptide T7 phage display technology

Kotaro Sakamoto, Yusuke Kamada, Tomoya Sameshima et al. · Biochemical and Biophysical Research Communications · 2017 · 114 citations

Pharmacy, Chemical Biology, Protein Engineering +9

Activation of NF-κB by the RANKL/RANK system up-regulates snail and twist expressions and induces epithelial-to-mesenchymal transition in mammary tumor cell lines

Masanobu Tsubaki, Makiko Komai, Shinichiro Fujimoto et al. · Journal of Experimental & Clinical Cancer Research · 2013 · 108 citations · Full text

Life Sciences, Cell Biology, Oncology +17

Generation of KS-58 as the first K-Ras(G12D)-inhibitory peptide presenting anti-cancer activity in vivo

Kotaro Sakamoto, Teruaki Masutani, Takatsugu Hirokawa · Scientific Reports · 2020 · 84 citations · Full text

Medicine, Oncology, Pharmacology +16

Crystal Structure of a Human K-Ras G12D Mutant in Complex with GDP and the Cyclic Inhibitory Peptide KRpep-2d

Satoshi Sogabe, Yusuke Kamada, Masanori Miwa et al. · ACS Medicinal Chemistry Letters · 2017 · 83 citations · Full text

Life Sciences, Molecular Biology, Oncology +17

Nitrogen-containing bisphosphonates inhibit RANKL- and M-CSF-induced osteoclast formation through the inhibition of ERK1/2 and Akt activation

Masanobu Tsubaki, Makiko Komai, Tatsuki Itoh et al. · Journal of Biomedical Science · 2014 · 70 citations · Full text

Medicine, Cell Biology, Pharmacology +15