K-Ras(G12D)-selective inhibitory peptides generated by random peptide T7 phage display technology

Kotaro Sakamoto, Yusuke Kamada, Tomoya Sameshima, +9

Biochemical and Biophysical Research Communications

BiochemistryMedicineNatural SciencesPeptide EngineeringPeptide Library +7

A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells

Yoshinori Ishikawa, Kanae Gamo, Masato Yabuki, +18

Molecular Cancer Therapeutics

Demethylase 1AMixed-phenotype Acute LeukemiaMyeloid NeoplasiaHematological MalignancySignaling Pathway +15

LSD1 Inhibitor T-3775440 Inhibits SCLC Cell Proliferation by Disrupting LSD1 Interactions with SNAG Domain Proteins INSM1 and GFI1B

Shinji Takagi, Yoshinori Ishikawa, Akio Mizutani, +5

Cancer Research

Crystal Structure of a Human K-Ras G12D Mutant in Complex with GDP and the Cyclic Inhibitory Peptide KRpep-2d

Satoshi Sogabe, Yusuke Kamada, Masanori Miwa, +7

ACS Medicinal Chemistry Letters

Crystal StructureProtein AssemblyMolecular BiologyCell DifferentiationCancer Biology +16

Functional and Physical Interaction of Yeast Mgs1 with PCNA: Impact on <i>RAD6</i>-Dependent DNA Damage Tolerance

Takashi Hishida, Tomoko Ohya, Yoshino Kubota, +2

Molecular and Cellular Biology

Dna DamageGeneticsGenomic MechanismMolecular BiologyPhysical Interaction +17

Discovery of GPX4 inhibitory peptides from random peptide T7 phage display and subsequent structural analysis

Kotaro Sakamoto, Satoshi Sogabe, Yusuke Kamada, +4

Biochemical and Biophysical Research Communications

BiochemistryNatural SciencesPeptide EngineeringPeptide LibraryMolecular Biology +8

Discovery of a B-Cell Lymphoma 6 Protein–Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach

Yusuke Kamada, Nozomu Sakai, Satoshi Sogabe, +9

Journal of Medicinal Chemistry

Discovery of selective ATP-competitive eIF4A3 inhibitors

Masahiro Ito, Misa Iwatani, Yusuke Kamada, +7

Bioorganic & Medicinal Chemistry

Drug TargetBiochemistryMedicineNatural SciencesDrug Development +3

T-448, a specific inhibitor of LSD1 enzyme activity, improves learning function without causing thrombocytopenia in mice

Satoru Matsuda, Rina Baba, Hideyuki Oki, +14

Neuropsychopharmacology

Specific InhibitorMedicineImmunologyNeuroscienceLsd1 Enzyme Activity +2

Hes1 suppresses acute myeloid leukemia development through FLT3 repression

Takeharu Kato, Mamiko Sakata‐Yanagimoto, Hidekazu Nishikii, +15

Leukemia

Hematological MalignancyChromatinMixed-phenotype Acute LeukemiaFlt3 RepressionMedicine +3