K-Ras(G12D)-selective inhibitory peptides generated by random peptide T7 phage display technology

Kotaro Sakamoto, Yusuke Kamada, Tomoya Sameshima, +9

Biochemical and Biophysical Research Communications

BiochemistryMedicineNatural SciencesPeptide EngineeringPeptide Library +7

Discovery of Potent Mcl-1/Bcl-xL Dual Inhibitors by Using a Hybridization Strategy Based on Structural Analysis of Target Proteins

Yuta Tanaka, Katsuji Aikawa, Goushi Nishida, +13

Journal of Medicinal Chemistry

Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation

Nobumichi Ohoka, Yoko Morita, Katsunori Nagai, +15

Journal of Biological Chemistry

Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation

Kenichiro Shimokawa, Norihito Shibata, Tomoya Sameshima, +7

ACS Medicinal Chemistry Letters

Development of protein degradation inducers of oncogenic <scp>BCR</scp>‐<scp>ABL</scp> protein by conjugation of <scp>ABL</scp> kinase inhibitors and <scp>IAP</scp> ligands

Norihito Shibata, Naoki Miyamoto, Katsunori Nagai, +8

Cancer Science

Crystal Structure of a Human K-Ras G12D Mutant in Complex with GDP and the Cyclic Inhibitory Peptide KRpep-2d

Satoshi Sogabe, Yusuke Kamada, Masanori Miwa, +7

ACS Medicinal Chemistry Letters

Crystal StructureProtein AssemblyMolecular BiologyCell DifferentiationCancer Biology +16

Discovery of 3-Benzyl-1-(<i>trans</i>-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12) Inhibitors

Masahiro Ito, Toshio Tanaka, Akinori Toita, +16

Journal of Medicinal Chemistry

Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER)

Nobumichi Ohoka, Osamu Ujikawa, Kenichiro Shimokawa, +6

Chemical and Pharmaceutical Bulletin

ApoptosisMolecular BiologyCell DeathDifferent Degradation MechanismsAnti-cancer Agent +14

Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase

Norihito Shibata, Kenichiro Shimokawa, Katsunori Nagai, +8

Scientific Reports

Rapid Determination of the Specificity Constant of Irreversible Inhibitors (<i>k</i>_inact/<i>K</i>_I) by Means of an Endpoint Competition Assay

Ikuo Miyahisa, Tomoya Sameshima, Mark S. Hixon

Angewandte Chemie International Edition

Pharmaceutical SciencePharmaceutical ResearchQuantitative PharmacologyEndpoint Competition AssayPharmacotherapy +22